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Security and performance of clonidine extended-release tablets have actually not been studied in children with ADHD much less compared to 6 years aged.

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In view of the retinal degeneration seen in rats, eye exams were done during medical tests in 908 grown-up clients prior to, and also regularly after, the beginning of clonidine therapy for high blood pressure.

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In 353 of these 908 people, the eye exams were performed over durations of 24 months or longer.

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A research was performed in which youthful rats were treated by mouth with clonidine hydrochloride from day 21 of age to adulthood at doses of up to 300 mcg/kg/day, which is roughly 3 times the max suggested human dose (MRHD) of 0.4 mg/day on a mg/m2 basis.

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